21:00 – tirsdag 5 november
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| Valencia | 4-1 | Lille |
Fuldtid
 | ||
Kevin Gameiro Rodrigo |  | 90' |
| 4-1 Ferrán Torres |  | 90' |
| 89' | | Jonathan Bamba Adama Soumaoro |
| 3-1 Geoffrey Kondogbia | | 84' |
2-1 Adama Soumaoro Selvmål |  | 82' |
| 80' |  | Domagoj Bradarić |
| 80' | | Luiz Araujo Benjamin André |
| 74' | | Renato Sanches Yusuf Yazıcı |
| Daniel Wass | | 67' |
1-1 Dani Parejo Straffespark |  | 66' |
| 65' | | José Fonte |
Manuel Vallejo Lee Kangin | | 54' |
| Pause 0-1 | ||
| 37' | | Benjamin André |
| Ezequiel Garay | | 31' |
Ferrán Torres Denis Cheryshev | | 30' |
| 25' | | 0-1 Victor Osimhen |
| 21' | | Gabriel |
| ||